Search results for " RON"
showing 10 items of 19 documents
Hereditary Leiomyomatosis and Renal Cell Cancer Syndrome in Spain: Clinical and Genetic Characterization
2020
Simple Summary Hereditary leiomyomatosis and renal cell cancer (HLRCC) syndrome is a very rare hereditary disorder characterized by cutaneous leiomyomas (CLMs), uterine leiomyomas (ULMs), renal cysts (RCys) and renal cell cancer (RCC), with no data on its prevalence worldwide. No genotype-phenotype associations have been described. The aim of our study was to describe the genotypic and phenotypic features of the largest series of patients with HLRCC from Spain reported to date. Of 27 FH germline pathogenic variants, 12 were not previously reported in databases. Patients with missense pathogenic variants showed higher frequencies of CLMs, ULMs and RCys, than those with loss-of-function varia…
Le lenti del cavalleresco nel secondo Novecento
2012
SF3B1 modulators affect key genes in metastasis and drug influx: a new approach to fight pancreatic cancer chemoresistance.
2021
Aim: Because mutations of splicing factor 3B subunit-1 (SF3B1) have been identified in 4% of pancreatic ductal adenocarcinoma (PDAC) patients, we investigated the activity of new potential inhibitors of SF3B1 in combination with gemcitabine, one of the standard drugs, in PDAC cell lines. Methods: One imidazo[2,1-b][1,3,4]thiadiazole derivative (IS1) and three indole derivatives (IS2, IS3 and IS4), selected by virtual screening from an in-house library, were evaluated by the sulforhodamine-B and wound healing assay for their cytotoxic and antimigratory activity in the PDAC cells SUIT-2, Hs766t and Panc05.04, the latter harbouring the SF3B1 mutations. The effects on the splicing pattern of pr…
«Mostruoso a vedere un Pergolesi coi baffi». Il mito in scena nel 1857 tra Milano (Solera - Ronchetti Monteviti) e Napoli (Quercia - Serrao)
2015
During the Nineteenth Century, the fame reached by Giovanni Battista Pergolesi was so large that the historical figure of the composer born in Jesi was transformed in a “dramatis persona”. Pergolesi appears as a character in two different operas dated to 1857. The first one is “Pergolese” by Temistocle Solera and Stefano Ronchetti Monteviti, performed in Milan at the Teatro alla Scala; the second one is “Pergolesi”, a “melodramma semiserio” by Fedrico Quercia set to music by Paolo Serrao and staged at the Teatro del Fondo in Naples. The two works mix historical elements with details drawn from pure fantasy. Their main purpose is to exalt the figure of the unfortunate and tormented artist, t…
Survival time and differences between dementia with Lewy bodies and Alzheimer’s disease following diagnosis: a meta-analysis of longitudinal studies.
2019
Objective: To synthesize the evidence across longitudinal studies comparing survival in dementia with Lewy bodies (DLB) and Alzheimer's disease (AD). Methods: We conducted a systematic review and meta-analysis of studies comparing survival in clinically diagnosed DLB to AD. Longitudinal cohort studies were identified through a systematic search of major electronic databases from inception to May 2018. A random effects meta-analysis was performed to calculate survival time and relative risk of death. Results: Overall, 11 studies were identified including 22,952 patients with dementia: 2029 with DLB (mean diagnosis age 76.3; 47% female) compared with 20,923 with AD (mean diagnosis age 77.2; 6…
Effectiveness, safety/tolerability of OBV/PTV/r ± DSV in patients with HCV genotype 1 or 4 with/without HIV-1 co-infection, chronic kidney disease (C…
2019
Background and aims Limited data are available on the effectiveness and tolerability of direct-acting antivirals (DAAs) therapies in the real world for HCV-infected patients with comorbidities. This study aimed to describe the effectiveness of OBV/PTV/r +/- DSV (3D/2D regimen) with or without ribavirin (RBV) in HCV or HCV/HIV co-infected patients with GT1/GT4 and CKD (IIIb-V stages), including those under hemodialysis and peritoneal dialysis in routine clinical practice in Spain in 2015. Material and methods Non-interventional, retrospective, multicenter data collection study in 31 Spanish sites. Socio-demographic, clinical variables, study treatment characteristics, effectiveness and toler…
Non-valvular Atrial Fibrillation in CKD: Role of Vitamin K Antagonists and Direct Oral Anticoagulants. A Narrative Review
2021
Atrial fibrillation (AF) is the most common arrhythmia in chronic kidney disease (CKD), with a close bidirectional relationship between the two entities. The presence of CKD in AF increases the risk of thromboembolic events, mortality and bleeding. Vitamin K antagonists (VKA) have been the mainstay of treatment for the prevention of thromboembolic events in AF until recently, with confirmed benefits in AF patients with stage 3 CKD. However, the risk-benefit profile of VKA in patients with AF and stages 4–5 CKD is controversial due to the lack of evidence from randomized controlled trials. Treatment with VKA in CKD patients has been associated with conditions such as poorer anticoagulation q…
Ronchamp: dalla stalla di Gut Garkau alla moschea di Sidi Brahim Ronchamp: from Gut Garkau stable to Sidi Brahim mosque
2015
Nel percorrere itinerari storici, apparentemente opposti, da una parte all'interno del Movimento Moderno e dall'altra attraverso lo studio delle moschee di El Atteuf (Algeria), si riscontra un punto di intersezione conosciuto ma inaspettato: la cappella di Ronchamp di Le Corbusier. Ronchamp dimostra come impossibili o quanto mai arbitrarie siano le catalogazioni di un’opera del genere, la quale può essere considerata sia come momento di sintesi del moderno (e non soltanto del Movimento Moderno), sia come trait d’union fra due diversi mondi, l’islamico e il cristiano, integrati spesso soltanto all’interno di un rapporto di forza che ha visto prevalere, a seconda dei tempi, l’uno o l’altro se…
Luca Ronconi e il meraviglioso nell'opera: il caso Monteverdi
2021
Luca Ronconi staged Monteverdi's Orfeo in Florence, at Goldoni Theater in 1998. The present article discusses this production in the context of Ronconi's activity as opera director; the Baroque idea of "meraviglia" is also taken into account.
Els morts agraïts
2018
Mahiques Climent, Joan: Els morts agraïts. Manacor: Món de Llibres, 2016, 196 p.